A Consultant Cardiologist, based in London, who is dedicated to delivering expert, compassionate cardiac care that prioritises heart health.
Whether a patient is managing a known heart condition or seeking to prevent one, Dr Sen provides guidance at every stage. By combining the latest evidence-based treatments with a personalised approach, Dr Sen ensures that care is tailored to each individual’s unique needs.
Patients receive the clarity, support, and expert guidance needed to make informed decisions about their heart health.
His goal is to help each person live a longer, healthier life – with a stronger heart. Through proactive steps, he aims to protect cardiovascular well-being and provide peace of mind for the future.
Dr Sayan Sen is an internationally recognised consultant interventional cardiologist based in London. He is a Founding Partner at One Heart Clinic, and performs procedures at the Cromwell Hospital and Cleveland Clinic London.
His clinical expertise spans the full breadth of interventional and general cardiology. He routinely performs complex coronary angioplasty and stenting, TAVI (transcatheter aortic valve implantation), pacemaker insertion, implantable loop recorder implantation, and renal denervation for resistant hypertension. He is recognised as one of the UK’s foremost TAVI and angioplasty specialists and is invited to perform procedures as a live case operator at international cardiology conferences — demonstrating techniques to cardiologists from around the world.
Dr Sen studied medicine at University College London, graduating with Distinction and a first-class Honours BSc in Medical Sciences and Neuroscience. He was awarded the prestigious MRC Research Fellowship in 2009 to study coronary haemodynamics at Imperial College London, where he completed his PhD.
His academic awards include the Royal Society of Medicine Investigator of the Year Award — All Sections (2013), the Royal Society of Medicine President’s Gold Medal in Cardiology (2013), and the Imperial College Armstrong Medal and Prize (2012). He has also received Young Investigator Awards at leading international meetings in Amsterdam and at the British Cardiac Intervention Society.
Dr Sen is perhaps best known as the co-developer of iFR — the instantaneous wave-free ratio. During his PhD at Imperial College London, he identified that there exists a naturally occurring period within each heartbeat during which coronary blood flow can be measured accurately without the need for any vasodilatory medication. This insight led to the development of iFR: a simpler, more comfortable, and equally accurate alternative to the previously established technique of FFR (fractional flow reserve).
iFR has since been validated in two landmark randomised controlled trials — DEFINE-FLAIR and iFR-SWEDEHEART — both published simultaneously in the New England Journal of Medicine in 2017. The technique was subsequently incorporated into American and European cardiology guidelines and is now used in over 6,000 hospitals worldwide to guide coronary stent decisions. It is one of the most significant innovations in interventional cardiology of the past two decades.
Alongside his academic and procedural work, Dr Sen is committed to a model of care that places the individual at the centre. He believes that excellent cardiology is not only about technical precision — it is about ensuring that every patient understands their condition, feels genuinely heard, and has the information they need to make confident decisions about their heart health.
Whether you are seeking a first opinion on unexplained symptoms, pursuing a diagnosis after years of uncertainty, or facing a complex cardiac procedure, Dr Sen and his team are here to provide the clarity, expertise, and personalised care that every patient deserves.
Hearing from other patients can be reassuring. The honest stories and experiences shared on this site reflect the care, trust, and results Dr Sen strives to deliver to each individual.
When under Dr Sen’s care, patients experience more than just expert treatment – they feel seen, heard, and supported. He has created an environment built on trust, empathy, and expertise, where comfort and confidence come first.
Your heart health truly matters.
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